ncRNA name | Rictor shRNA |
ncRNA Category | shRNA |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | human cutaneous cell line A375; human UM cell line MUM‐2B |
Methods | immunohistochemical staining, plasmid transfection, MTT assay, cell cycle analysis, transwell assay, wound‐healing assay, adhesion assay, Western blot, qPCR, zymography assay |
Expression pattern | associated |
Functional description | Rictor knockdown by short hairpin RNA (shRNA) significantly inhibited the ability of A375 and MUM-2B melanoma cells to form VM structures. Rictor knockdown blocked cell growth and resulted in the accumulation of cells in G2/M phase, and cell migration and invasion were greatly affected after Rictor down-regulation. |
PubMed ID | 28699701 |
Year | 2017 |
Title | Rictor regulates the vasculogenic mimicry of melanoma via the AKT-MMP-2/9 pathway. |
Drug-related ncRNA | NA |
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